Unconventional localization of PAI-1 in PML bodies: A possible link with cellular growth of endothelial cells

• DOI: 10.1016/j.bbrep.2024.101793
• Publication Date: 2024-07-26T17:59:06Z
• Authors: Pragya Gehlot; Daniela Brünnert; Vibha Kaushik; Arpana Yadav; Saloni Bage; Kritika Gaur; Mahesh Saini; Jens Ehrhardt; Gowrang Kasaba Ma...; Abhishek Kumar; Neena Kasliwal; Ajay Kumar Sharma; Marek Zygmunt; Pankaj Goyal
• Keywords: Serpin; Plasminogen activator inhibitor-1

Plasminogen activator inhibitor-1 (PAI-1/Serpin E1) is classically known for its antifibrinolytic activity via inhibiting uPA and tPA of the fibrinolytic pathway. PAI-1 has a paradoxical role in tumor progression, molecular functions are poorly understood. widely accepted secretory protease inhibitor, however, study suggested localization cytoplasm nucleus. Besides plethora biological as protein, intracellular localization, remain unexplored at level. In this study, using various