Mn-containing bioceramics inhibit osteoclastogenesis and promote osteoporotic bone regeneration via scavenging ROS

• DOI: 10.1016/j.bioactmat.2021.03.039
• Publication Date: 2021-04-14T05:43:46Z
• Authors: Jianmei Li; Cuijun Deng; Wanyuan Liang; Fei Kang; Yun Bai; Bing Ma; Chengtie Wu; Shiwu Dong
• Keywords: Bioceramic

Osteoporosis is caused by an osteoclast activation mechanism. People suffering from osteoporosis are prone to bone defects. Increasing evidence indicates that scavenging reactive oxygen species (ROS) can inhibit receptor activator of nuclear factor κB ligand (RANKL)-induced osteoclastogenesis and suppress ovariectomy-induced osteoporosis. It critical develop biomaterials with antioxidant properties modulate activity for treating osteoporotic Previous studies have shown manganese (Mn) improve regeneration, Mn supplementation may treat However, the effect on osteoclasts role in defects remain unclear. In present research, a model bioceramic, Mn-contained β-tricalcium phosphate (Mn-TCP) was prepared introducing into β-TCP. The introduction β-TCP significantly improved radicals nitrogen radicals, demonstrating Mn-TCP bioceramics might properties. vitro vivo findings revealed Mn2+ ions released could distinctly formation function osteoclasts, promote differentiation osteoblasts, accelerate regeneration under conditions vivo. Mechanistically, inhibited promoted ROS via Nrf2 activation. These results suggest Mn-containing osteoconductivity, resorption inhibition abilities be ideal biomaterial treatment defect.