Photoacoustic and magnetic resonance imaging-based gene and photothermal therapy using mesoporous nanoagents

• DOI: 10.1016/j.bioactmat.2021.07.025
• Publication Date: 2021-07-28T11:48:46Z
• Authors: Hao Huang; Guotao Yuan; Ying Xu; Yuan Gao; Qiulian Mao; Yin Zhang; Lu Bai; Weijie Li; Anqing Wu; Wentao Hu; Yue Pan; Guangming Zhou
• Keywords: 0301 basic medicine; 03 medical and health sciences; QH301-705.5; Gene therapy (GT); TA401-492; Photothermal therapy (PTT); Long noncoding RNA CRYBG3; Biology (General); Materials of engineering and construction. Mechanics of materials; Article; Porous iron oxide nanoagents (PIONs); 3. Good health

The integration of photothermal therapy (PTT) with gene (GT) in a single nanoscale platform demonstrates great potential cancer therapy. Porous iron oxide nanoagents (PIONs) are widely used as magnetic the drug delivery field and also serve nanoagent for However, therapeutic efficacy PIONs-mediated GT has not been studied. long noncoding RNA (lncRNA) CRYBG3 (LNC CRYBG3), lncRNA induced by heavy ion irradiation lung cells, reported to directly bind globular actin (G-actin) cause degradation cytoskeleton blocking cytokinesis, thus indicating its use simulating effect functioning an antitumor drug. In present study, we investigated possibility combining PTT LNC CRYBG3-mediated destroy non-small cell (NSCLC) cells both vitro vivo. combination showed high killing efficacy, cure rate was better than that achieved using or alone. Moreover, type nanoagent, PIONs can be resonance imaging (MRI) photoacoustic (PAI) These findings indicate new treatment.