Synergistic osteogenic and angiogenic effects of KP and QK peptides incorporated with an injectable and self-healing hydrogel for efficient bone regeneration

• DOI: 10.1016/j.bioactmat.2022.02.011
• Publication Date: 2022-02-25T14:34:05Z
• Authors: Runze Li; Chen Zhou; Jun Chen; Haotian Luo; Ruoyu Li; Danying Chen; Xuenong Zou; Weicai Wang
• Keywords: Calvaria; Gelatin; Self-assembling peptide

Irregular defects generated by trauma or surgery in orthopaedics practice were usually difficult to be fitted the preformed traditional bone graft substitute. Therefore, injectable hydrogels have attracted an increasing interest for repair because of their fittability and mini-invasivity. However, uncontrollable spreading mechanical failures during its manipulation remain a problem solved. Moreover, order achieve vascularized regeneration, alternatives osteogenic angiogenic growth factors should adopted avoid immunogenicity high cost. In this study, novel self-healing hydrogel system (GMO hydrogel) loaded with KP QK peptides had been developed enhancing regeneration small irregular defect. The dynamic imine bonds between gelatin methacryloyl oxidized dextran provided GMO shear-thinning abilities, which led excellent injectability fittability. By photopolymerization enclosed GelMA, was further strengthened thus more suitable regeneration. Besides, peptide tethered Schiff base reaction, leading desired releasing profiles.