Plant-derived nanovesicles: Current understanding and applications for cancer therapy

• DOI: 10.1016/j.bioactmat.2022.10.005
• Publication Date: 2022-10-20T11:54:20Z
• Authors: Ngoc Phung Ly; Hwa Seung Han; Myungsuk Kim; Jae Hyung Park; Ki Young Choi
• Keywords: 0301 basic medicine; Cancer therapy; Anti-cancer; QH301-705.5; Plant-derived vesicles; Extracellular vesicles; Article; 3. Good health; 03 medical and health sciences; Drug delivery; TA401-492; Biology (General); Materials of engineering and construction. Mechanics of materials

Plant-derived vesicles (PDVs) are membranous structures that originate from plant cells and are responsible for multiple physiological and pathological functions. In the last decade, PDVs have gained much attention for their involvement in different biological processes, including intercellular communication and defense response, and recent scientific evidence has opened a new avenue for their applications in cancer treatment. Nevertheless, much remains unknown about these vesicles, and current research remains inconsistent. This review aims to provide a comprehensive introduction to PDVs, from their biological characteristics to purification methods, and to summarize the status of their potential development for cancer therapy.