Transplantation of neural stem progenitor cells from different sources for severe spinal cord injury repair in rat

• DOI: 10.1016/j.bioactmat.2022.11.008
• Publication Date: 2022-11-23T20:55:44Z
• Authors: Bai Xu; Man Yin; Yaming Yang; Yunlong Zou; Wenbin Liu; Lianyong Qiao; Jixiang Zhang; Zhan Wang; Yayu Wu; He Shen; Minghan Sun; Weiyuan Liu; Weiwei Xue; Yongheng Fan; Qi Zhang; Bing Chen; Xianming Wu; Ya Shi; Falong Lu; Yannan Zhao; Zhifeng Xiao; Jianwu Dai
• Keywords: 0301 basic medicine; 03 medical and health sciences; Spinal cord-derived NSPCs; Collagen scaffolds; QH301-705.5; TA401-492; H9 embryonic stem cell-derived NSPCs; Spinal cord injury; Brain-derived NSPCs; Biology (General); Materials of engineering and construction. Mechanics of materials; Article

Neural stem progenitor cell (NSPC) transplantation has been regarded as a promising therapeutic method for spinal cord injury (SCI) repair. However, different NSPCs may have effects, and it is therefore important to identify the optimal NSPC type. In our study, we compared transcriptomes of human fetal brain-derived (BNSPCs), cord-derived (SCNSPCs) H9 embryonic stem-cell derived (H9-NSPCs) in vitro subsequently transplanted each type on collagen scaffold into T8-9 complete SCI rat model vivo. data showed that SCNSPCs had more highly expressed genes involved nerve-related functions than other two types. vivo, with BNSPCs H9-NSPCs, exhibited best effects; fact, facilitated electrophysiological hindlimb functional recovery. This study demonstrates be an appropriate candidate repair, which great clinical significance.