Exosomes-loaded electroconductive nerve dressing for nerve regeneration and pain relief against diabetic peripheral nerve injury

• DOI: 10.1016/j.bioactmat.2023.02.024
• Publication Date: 2023-03-04T16:01:14Z
• Authors: Qinfeng Yang; Shenghui Su; Shencai Liu; Sheng Yang; Jing Xu; Yixiu Zhong; Yusheng Yang; Liangjie Tian; Zilin Tan; Jian Wang; Zhiqiang Yu; Zhanjun Shi; Fangguo Liang
• Keywords: Nerve Injury; Nerve guidance conduit; Peripheral nerve injury

Over the years, electroconductive hydrogels (ECHs) have been extensively applied for stimulating nerve regeneration and restoring locomotor function after peripheral injury (PNI) with diabetes, given their favorable mechanical electrical properties identical to endogenous tissue. Nevertheless, PNI causes loss of inflammatory pain, especially in diabetic patients. It has established that bone marrow stem cells-derived exosomes (BMSCs-Exos) analgesic, anti-inflammatory tissue properties. Herein, we designed an ECH loaded BMSCs-Exos (ECH-Exos) dressing treat achieve functional recovery pain relief. Given its potent adhesive self-healing properties, this laminar is convenient treatment damaged fibers by automatically wrapping around them form a size-matched tube-like structure, avoiding cumbersome implantation process. Our vitro studies showed ECH-Exos could facilitate attachment migration Schwann cells. Meanwhile, Exos system modulate M2 macrophage polarization via NF-κB pathway, thereby attenuating PNI. Additionally, enhanced myelinated axonal MEK/ERK pathway vivo, consequently ameliorating muscle denervation atrophy further promoting restoration. findings suggest huge prospects regeneration, restoration relief patients