Exosomes derived from impaired liver aggravate alveolar bone loss via shuttle of Fasn in type 2 diabetes mellitus

• DOI: 10.1016/j.bioactmat.2023.10.022
• Publication Date: 2023-11-09T12:04:38Z
• Authors: Jiani Liu; Geng Dou; Wanmin Zhao; Ji'an Hu; Zhiwei Jiang; Wenzhe Wang; Hanzhe Wang; Shiyu Liu; Yan Jin; Yimin Zhao; Qianming Chen; Bei Li
• Keywords: Pyroptosis; Mediator

Type 2 diabetes mellitus (T2DM) exacerbates irreversible bone loss in periodontitis, but the mechanism of impaired regeneration caused by abnormal metabolic process T2DM remains unclear. Exosomes are regarded as critical mediator diabetic impairment via organ or tissue communication. Here, we find that abnormally elevated exosomes derived from metabolically liver significantly enriched periodontal region and induced pyroptosis ligament cells (PDLCs). Mechanistically, fatty acid synthase (Fasn), main differentially expressed molecule results ectopic synthesis PDLCs activates cleavage gasdermin D. Depletion Fasn effectively mitigates alleviates loss. Our findings elucidate exacerbated periodontitis reveal exosome-mediated communication "liver-bone" axis, which shed light on prevention treatment disorders future.