Antibiofilm and antithrombotic hydrogel coating based on superhydrophilic zwitterionic carboxymethyl chitosan for blood-contacting devices

• DOI: 10.1016/j.bioactmat.2023.12.009
• Publication Date: 2023-12-19T12:52:27Z
• Authors: Dong Uk Lee; Mukhammad Kayumov; Junghun Park; Se Kye Park; Yeongkwon Kang; Yejin Ahn; Woojin Kim; Seung Hwa Yoo; Jun-Kyu Park; Bong-Gi Kim; Yong Suk Oh; In-Seok Jeong; Dong Yun Choi
• Keywords: Biocompatibility; Thrombogenicity; Superhydrophilicity; Hemostatic Agent; Surface Modification

Blood-contacting devices must be designed to minimize the risk of bloodstream-associated infections, thrombosis, and intimal lesions caused by surface friction. However, achieving effective prevention both infections thrombosis poses a challenge due conflicting nature antibacterial antithrombotic activities, specifically regarding electrostatic interactions. This study introduced novel biocompatible hydrogel sodium alginate zwitterionic carboxymethyl chitosan (ZW@CMC) with activities for use in catheters. The ZW@CMC demonstrates superhydrophilic good hygroscopic properties, which facilitate formation stable hydration layer low zwitterionic-functionalized CMC incorporates an additional negative sulfone group increased charge density carboxyl group. augmentation enhances repulsion facilitates layer. leads exceptional blood clotting factor adhesion inhibition biofilm formation. Subsequently, exhibited biocompatibility tests