Urchin-like multiscale structured fluorinated hydroxyapatite as versatile filler for caries restoration dental resin composites

• DOI: 10.1016/j.bioactmat.2024.02.004
• Publication Date: 2024-02-19T19:39:45Z
• Authors: Shuning Zhang; Xiao Wang; Shi Yin; Junjun Wang; Hongyan Chen; Xinquan Jiang
• Keywords: Filler (materials); Resin composite

Caries is one of the most prevalent human diseases, resulting from demineralization tooth hard tissue caused by acids produced bacteria, and can progress to pulpal inflammation. Filling restoration with dental resin composites (DRCs) currently common treatment for caries. However, existing DRCs suffer low fracture strength lack comprehensive anti-caries bioactivity including remineralization, pulp protection, anti-cariogenic bacteria effects. In this study, inspired plant roots' ability stabilize improve soil, fluorinated urchin-like hydroxyapatite (FUHA) a three-dimensional whisker structure bioactive components calcium, phosphorus, fluorine was designed synthesized dynamic self-assembly method. Furthermore, versatile FUHA particles different loading fractions were used as functional fillers fabricate methacrylate-based DRCs, where (UHA) filled commercial (Z350XT BEAUTIFIL II) served control groups. The results demonstrated that 50 wt% in matrix endowed DRC (F5) excellent physicochemical properties, dentin remineralization property, cell viability, promotion stem cells mineralization, antibacterial properties. Meanwhile, F5 also presented good clinical handling aesthetic characteristics. Therefore, structure/functional-integrated have potential promising strategy bioactivity.