NIR-enhanced Pt single atom/g-C3N4 nanozymes as SOD/CAT mimics to rescue ATP energy crisis by regulating oxidative phosphorylation pathway for delaying osteoarthritis progression

• DOI: 10.1016/j.bioactmat.2024.02.018
• Publication Date: 2024-02-21T00:44:31Z
• Authors: Jianhui Xiang; Xin Yang; Manli Tan; Jianfeng Guo; Yuting Ye; Jiejia Deng; Zhangrui Huang; Hanjie Wang; Wei Su; Jianwen Cheng; Li Zheng; Sijia Liu; Jingping Zhong; Jinmin Zhao
• Keywords: 0303 health sciences; 03 medical and health sciences; QH301-705.5; Oxidative phosphorylation pathway; TA401-492; Nanozymes; Osteoarthritis progression; Biology (General); ATP energy crisis; Materials of engineering and construction. Mechanics of materials; Article

Osteoarthritis (OA) progresses due to the excessive generation of reactive oxygen and nitrogen species (ROS/RNS) abnormal ATP energy metabolism related oxidative phosphorylation pathway in mitochondria. Highly active single-atom nanozymes (SAzymes) can help regulate redox balance have shown their potential treatment inflammatory diseases. In this study, we innovatively utilised ligand-mediated strategies chelate Pt