Recovering skin-nerve interaction by nanoscale metal-organic framework for diabetic ulcers healing

• DOI: 10.1016/j.bioactmat.2024.08.024
• Publication Date: 2024-08-29T17:27:40Z
• Authors: Xiuru Ji; Jingwei Zhou; Zengding Zhou; Zeyang Liu; Li Yan; Yuhan Li; Haiyan Guo; Weijie Su; Han Wang; Dalong Ni
• Keywords: Diabetic Neuropathy

Skin-nerve interaction plays an important role in promoting wound healing. However, diabetic ulcers (DUs), the periphery neuropathy and excessive levels of reactive oxygen species (ROS) block skin-nerve further impede DUs Herein, we developed a nanoscale metal-organic framework loaded with nerve growth factor (NGF/Ce-UiO-66, denoted NGF/CU) for treatment DUs. The Ce-UiO-66 (CU) was applied as antioxidant to scavenge ROS reduce inflammatory response while NGF aided recovery cutaneous nerves promote Both