Long-term stable wireless smart contact lens for robust digital diabetes diagnosis

• DOI: 10.1016/j.biomaterials.2023.122315
• Publication Date: 2023-09-04T15:29:01Z
• Authors: Hye Hyeon Han; Su-Kyung Kim; Seong-Jong Kim; Inhoo Choi; Jee Won Mok; Choun-Ki Joo; Sangbaie Shin; Sei Kwang Hahn
• Keywords: Blood Glucose; Glucose; Contact Lenses; Blood Glucose Self-Monitoring; Diabetes Mellitus; Animals; Rabbits; 3. Good health; Glycosaminoglycans

Wearable devices for digital continuous glucose monitoring (CGM) have attracted great attention as a new paradigm medical device for diabetes management. However, the relatively inaccurate performance and instability of CGM devices have limited their wide applications in the clinic. Here, we developed hyaluronate (HA) modified Au@Pt bimetallic electrodes for long-term accurate and robust CGM of smart contact lens. After glucose oxidation reaction, the bimetallic electrodes facilitated the rapid decomposition of hydrogen peroxide and charge transfer for robust CGM. The passivation of Au@Pt bimetallic electrode with branch-type thiolated HA prevented the dissolution of Au electrode by chloride ions in tears. In diabetic and normal rabbits, the smart contact lens with HA-Au@Pt bimetallic electrodes enabled the high correlation (ρ = 0.88) CGM with 98.6% clinically acceptable data for 3 weeks. Taken together, we could confirm the feasibility of our smart contact lens for long-term CGM for further clinical development.