Gut microbiota of patients with type 2 diabetes and gastrointestinal intolerance to metformin differs in composition and functionality from tolerant patients

• DOI: 10.1016/j.biopha.2021.112448
• Publication Date: 2021-11-26T09:58:14Z
• Authors: Cristina Ma Díaz-...; Araceli Muñoz-Garach; María Dolores Álv...; Isabel Moreno-Indias; Francisco J. Tina...
• Keywords: Ruminococcus; Veillonella; Prevotella; Lachnospiraceae

Metformin modifies the gut microbiome in type 2 diabetes and gastrointestinal tolerance to metformin could be mediated by microbiome.We enrolled 35 patients with not receiving treatment due suspected intolerance. was reintroduced at 425 mg, increasing mg every two weeks until reaching 1700 per day. According occurrence of metformin-related symptoms, were classified into three groups: early intolerance, non-tolerant, tolerant. Gut microbiota profiled 16 S rRNA. This sequencing aimed determine differences baseline all groups prospectively tolerant non-tolerant groups.The classification resulted 15 intolerant, 10 tolerant, subjects. Early characterized a higher abundance Subdoligranulum; while Veillonella Serratia group. The group showed enrichment Megamonas, Megamonas rupellensis, Phascolarctobacterium spp; Ruminococcus gnavus lower longitudinal analysis. At end point Prevotellaceae, Prevotella stercorea, funiformis, Bacteroides xylanisolvens, Blautia producta had relative compared Subdoligranulum, torques_1, faecium, Eubacterium PICRUSt analysis activity amino acid biosynthesis pathways sugar degradation pathway intolerant groups.Gut subjects intolerance depicted taxonomic functional patients, this changed differently after administration.