Umbelliferone prevents isoproterenol-induced myocardial injury by upregulating Nrf2/HO-1 signaling, and attenuating oxidative stress, inflammation, and cell death in rats

• DOI: 10.1016/j.biopha.2022.112900
• Publication Date: 2022-04-01T11:58:59Z
• Authors: Osama Y. Althunibat; Maisa Siddiq Abduh; Mohammad H. Abukh...; Saleem H. Aladaileh; Hamza Hanieh; Ayman M. Mahmoud
• Keywords: Malondialdehyde; Coenzyme Q10

The role of oxidative injury and inflammatory response in cardiovascular diseases heart failure has been well-acknowledged. This study evaluated the protective effect umbelliferone (UMB), a coumarin with promising radical scavenging anti-inflammatory activities, on myocardial induced by isoproterenol (ISO) rats. Rats received 50 mg/kg UMB orally for 14 days 85 ISO twice at an interval 24 h. Administration elevated serum troponin I, creatine kinase-MB lactate dehydrogenase, caused histopathological alterations, including degeneration, fatty vacuolation, myolysis, atrophy fibers. Malondialdehyde (MDA), nitric oxide (NO), nuclear factor-kappaB (NF-κB) p65, tumor necrosis factor (TNF)-α, interleukin (IL)-6, IL-1β were increased, whereas reduced glutathione (GSH), superoxide dismutase (SOD), catalase decreased ISO-administered effectively ameliorated injury, alleviated cardiac function markers, MDA, NO, NF-κB mediators, enhanced cellular antioxidants. Bax, caspase-3, 8-OHdG decreased, Bcl-2 was increased rats treated UMB. In addition, upregulated factor-erythroid 2-related 2 (Nrf2) heme oxygenase (HO)-1 conclusion, can protect myocardium from response, cell death upregulating Nrf2/HO-1 signaling