The impact of Morus alba L. leaf extract on intestinal ion transport. An in vitro study

• DOI: 10.1016/j.biopha.2022.112939
• Publication Date: 2022-04-20T23:30:54Z
• Authors: Anna Gryn-Rynko; Iga Hołyńska-Iwan; Michał Adam Janiak; Dorota Olszewska-...; Ryszard Amarowicz; Radomir Graczyk
• Keywords: Transepithelial potential difference; Amiloride; Bumetanide; Moraceae

Morus alba L. (White mulberry), is an important and popular herbal plant of the Moraceae family. It has been widely used due to its therapeutic properties, which include antidiabetic, antibacterial, anti-inflammatory, cardiovascular, hypolpidemic activity. The present study evaluates effects aqueous white mulberry leaf extract on transepithelial ion pathway in rabbit colon epithelium (n = 48), using electrophysiological methods. In addition, antioxidant potential chemical composition were determined. A mechanical-chemical stimulation with RH fluid (MB-RH) caused a statistically significant (p < 0.001) increase electrical difference, from - 0.130 0.685 mV. Gentle washing intestine bumetanide, as inhibitor chloride pathways, resulted 14.8% shorter reaction than during MB-RH stimulation. There no differences between electric values measured amiloride solution, sodium amilorid solution 0.485). short-term application responsible for local reversible inhibition channels. enhances absorption consequently changes potential. effect transport may be related mechanism hypoglycaemic activity leaves.