The impact of Morus alba L. leaf extract on intestinal ion transport. An in vitro study
Transepithelial potential difference
Amiloride
Bumetanide
Moraceae
DOI:
10.1016/j.biopha.2022.112939
Publication Date:
2022-04-20T23:30:54Z
AUTHORS (6)
ABSTRACT
Morus alba L. (White mulberry), is an important and popular herbal plant of the Moraceae family. It has been widely used due to its therapeutic properties, which include antidiabetic, antibacterial, anti-inflammatory, cardiovascular, hypolpidemic activity. The present study evaluates effects aqueous white mulberry leaf extract on transepithelial ion pathway in rabbit colon epithelium (n = 48), using electrophysiological methods. In addition, antioxidant potential chemical composition were determined. A mechanical-chemical stimulation with RH fluid (MB-RH) caused a statistically significant (p < 0.001) increase electrical difference, from - 0.130 0.685 mV. Gentle washing intestine bumetanide, as inhibitor chloride pathways, resulted 14.8% shorter reaction than during MB-RH stimulation. There no differences between electric values measured amiloride solution, sodium amilorid solution 0.485). short-term application responsible for local reversible inhibition channels. enhances absorption consequently changes potential. effect transport may be related mechanism hypoglycaemic activity leaves.
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