Irisin improves diabetic cardiomyopathy-induced cardiac remodeling by regulating GSDMD-mediated pyroptosis through MITOL/STING signaling

• DOI: 10.1016/j.biopha.2023.116007
• Publication Date: 2024-01-03T10:56:44Z
• Authors: Linhe Lu; Yalan Shao; Xiang Xiong; Jipeng Ma; Mengen Zhai; Guofang Lu; Liqing Jiang; Ping Jin; Jiayou Tang; Jian Yang; Yang Liu; Weixun Duan; Jincheng Liu
• Keywords: Pyroptosis; Diabetic Cardiomyopathy; Pathogenesis; Sting

Diabetic cardiomyopathy (DCM) is a common complication of diabetes mellitus (DM). However, the mechanisms underlying DCM-induced cardiac injury remain unclear. Recently, role cyclic GMP-AMP synthase/stimulator interferon gene (cGAS/STING) signaling and pyroptosis in DCM has been investigated. Based on our previous results, this study was designed to examine impact irisin, mitochondrial ubiquitin ligase (MITOL/MARCH5), cGAS/STING dysfunction effect gasdermin D (GSDMD)-dependent pyroptosis. High-fat diet-induced mice H9c2 cells were used for geometry function or pyroptosis-related biomarker assessment at end experiments. Here, we show that impairs by increasing fibrosis GSDMD-dependent pyroptosis, including activation MITOL signaling. Our results confirmed protective irisin partially offset We also demonstrated plays pivotal pathological process pathogenesis. indicate treatment protects against injury, homeostasis, through upregulation.