Exerkine β-aminoisobutyric acid protects against atrial structural remodeling and atrial fibrillation in obesity via activating AMPK signaling and improving insulin sensitivity

• DOI: 10.1016/j.biopha.2024.116137
• Publication Date: 2024-01-13T12:47:02Z
• Authors: Xinghua Qin; Peng Liu; Lingyan Jin; Ke Zhu; Yuanqing Yang; Zuoxu Hou; Huiliang Zhang; Qiangsun Zheng
• Keywords: AMP-Activated Protein Kinase; Carbohydrate Metabolism

Moderate exercise decreases the risk for atrial fibrillation (AF), an effect which is probably mediated via exercise-stimulated release of exerkines. β-Aminoisobutyric acid (BAIBA), a novel exerkine, has been reported to provide protective benefits against many cardiovascular diseases, yet its role in AF remains elusive. Herein, using mouse model obesity-related through high-fat diet (HFD) feeding, we found that 12-week drinking administration BAIBA (170 mg/kg/day) decreased susceptibility obese mice. Atrial remodeling assessment showed attenuated obesity-induced hypertrophy and interstitial fibrosis, thereby ablating substrate AF. Of note, our knowledge, this first report direct association hypertrophy. be key regulator glucose lipid metabolism, alleviated insulin resistance Transcriptional analysis metabolism-related genes increased transcription fatty acids atria lean mice but not Mechanistic investigation stimulated AMP-activated protein kinase (AMPK) signaling palmitic (PA)-treated neonatal rat cardiomyocytes (NRCM), whereas inhibition AMPK Compound C BAIBA-conferred cardioprotection PA-treated NRCM. Collectively, attenuates activated resultant improvement sensitivity, providing perspectives on potential therapeutic treatment.