Emerging regulatory mechanisms in cardiovascular disease: Ferroptosis

• DOI: 10.1016/j.biopha.2024.116457
• Publication Date: 2024-03-22T08:54:28Z
• Authors: Sijie Jin; He Wang; Xiaohao Zhang; Mengyang Song; Bin Liu; Wei Sun
• Keywords: Pathogenesis; GPX4; Lipid peroxide

Ferroptosis, distinct from apoptosis, necrosis, autophagy, and other types of cell death, is a novel iron-dependent regulated death characterized by the accumulation lipid peroxides redox imbalance with morphological, biochemical, genetic features. Dysregulation iron homeostasis, disruption antioxidative stress pathways peroxidation are crucial in ferroptosis. Ferroptosis involved pathogenesis several cardiovascular diseases, including atherosclerosis, cardiomyopathy, myocardial infarction, ischemia-reperfusion injury, abdominal aortic aneurysm, dissection, heart failure. Therefore, comprehensive understanding mechanisms that regulate ferroptosis diseases will enhance prevention treatment these diseases. This review discusses latest findings on molecular its regulation application modulators role traditional Chinese medicines to provide identify new options.