Chlamydocin analogs bearing carbonyl group as possible ligand toward zinc atom in histone deacetylases

• DOI: 10.1016/j.bmc.2005.12.063
• Publication Date: 2006-01-27T14:55:03Z
• Authors: Mohammed P.I. Bhu...; Tamaki Kato; Tatsuo Okauchi; Norikazu Nishino; Satoko Maeda; Tomonori G. Nishino; Minoru Yoshida
• Keywords: Aldehydes; 0303 health sciences; Molecular Structure; Ketones; Ligands; Peptides, Cyclic; Cell Line; Histone Deacetylase Inhibitors; Structure-Activity Relationship; Zinc; 03 medical and health sciences; Humans; Enzyme Inhibitors; Cells, Cultured

A series of chlamydocin analogs with various carbonyl functionalities were designed and synthesized as histone deacetylase (HDAC) inhibitors. Chlamydocin is a cyclic tetrapeptide containing an epoxyketone surrogate in the side chain which makes it irreversible inhibitor of HDACs, whereas apicidins are a class of cyclic tetrapeptides that contain an ethylketone moiety as zinc ligand. We replaced the epoxyketone moiety of chlamydocin with several ketones and aldehyde to synthesize potent reversible and selective HDAC inhibitors. The inhibitory activity of the cyclic tetrapeptides against histone deacetylase enzymes were evaluated and the result showed most of them are potent inhibitors. Some of them have remarkable selectivity among the HDACs.