Glucose variability and low bone turnover in people with type 2 diabetes

• DOI: 10.1016/j.bone.2021.116159
• Publication Date: 2021-08-27T05:54:04Z
• Authors: Jakob Starup-Linde; Simon Lykkeboe; Aase Handberg; Peter Vestergaard; Pernille Høyem; Jesper Fleischer; Troels Krarup Hansen; Per Løgstrup Poulsen; Esben Laugesen
• Keywords: Bone remodeling; N-terminal telopeptide; Sclerostin; Glycated hemoglobin; Procollagen peptidase

Type 2 diabetes (T2D) is related to an increased fracture risk and low bone turnover. However, the mechanisms are not elucidated. In present study we investigate association between glycemic variability turnover markers.100 participants with T2D 100 age gender matched controls were included in this cross-sectional study. All equipped a continuous glucose monitoring (CGM) sensor for 3 days (CGMS iPro Continuous Glucose Recorder; Medtronic MiniMed). The dawn levels defined as morning period starting 1 h before breakfast ending post ingestion. On all serum (s)-C-terminal cross-linked telopeptide of type-I collagen (CTX), s-procollagen type amino terminal propeptide (P1NP), s-sclerostin measured.Participants displayed significantly lower resorption marker s-CTX formation s-P1NP compared controls. S-CTX was negatively associated mean amplitude excursions (MAGE) whereas only while it borderline MAGE (p = 0.05). among 50% highest lowest also after adjustment age, gender, glycated hemoglobin A1c (HbA1c), body mass index (BMI).We observed that rise markers. Future research needed determine whether reduction increase