Formononetin alleviates cerebral ischemia-reperfusion injury in rats by targeting the PARP-1/PARG/Iduna signaling pathway

• DOI: 10.1016/j.brainres.2024.148845
• Publication Date: 2024-03-05T16:23:20Z
• Authors: Jie Luo; Youde Cai; Dingling Wei; Liping Cao; Qiansong He; Yuanhua Wu

Formononetin has been demonstrated to protect against cerebral ischemia–reperfusion injury, however its mechanism be further researched. This study examined the effect of formononetin on injury in rats using PARP-1/PARG/Iduna signaling pathway. In male SD rats, a model was developed. Animals were randomly assigned one eight groups: Sham operation, operation + formononetin, MCAO, MCAO PARP inhibitor (PJ34) PJ34 PARG (Ethacridine lactate) and ethacridine lactate formononetin. The neurological deficit test, TTC staining, HE Nissl TUNEL western blotting utilized assess formononetin's protective effects rats. data show that can effectively alleviate dysfunction pathological changes brain tissue with reduce area infarction neuronal apoptosis, decrease protein levels PARP-1, PARG, Caspase-3, P53, AIF tissue, increase Iduna p-AKT. As result, we concluded improves by modulating