HER2 copy number quantification in primary tumor and cell-free DNA provides additional prognostic information in HER2 positive early breast cancer

• DOI: 10.1016/j.breast.2022.02.002
• Publication Date: 2022-02-08T13:30:21Z
• Authors: Xiaobin Chen; Yuxiang Lin; Zhengwen Jiang; Yan Li; Yihua Zhang; Ying Wang; Feng Yu; Wenhui Guo; Lili Chen; Minyan Chen; Wenzhe Zhang; Chuan Wang; Fangmeng Fu
• Keywords: Concordance; Nomogram; Adjuvant Therapy

The quantitative relationship between HER2 copy number and prognosis in positive adjuvant setting remain controversial, few studies have focused on to illustrate the potential clinical relevance of cfDNA. Our study aim develop a novel method quantification explore primary tumors or cfDNA early breast cancer.