The effect of meninges on the electric fields in TES and TMS. Numerical modeling with adaptive mesh refinement

• DOI: 10.1016/j.brs.2022.04.009
• Publication Date: 2022-04-18T06:29:58Z
• Authors: Konstantin Weise; William A. Wartman; Thomas R. Knösche; Aapo R. Nummenmaa; Sergey N. Makarov
• Keywords: Meninges; Solver

When modeling transcranial electrical stimulation (TES) and magnetic (TMS) in the brain, meninges - dura, arachnoid, pia mater are often neglected due to high computational costs.We investigate impact of meningeal layers on cortical electric field TES TMS while considering headreco segmentation as base model.We use T1/T2 MRI data from 16 subjects apply boundary element fast multipole method with adaptive mesh refinement, which enables us accurately solve this problem establish convergence at reasonable cost. We compare fields presence absence various for two brain areas (M1HAND DLPFC) several distinct setups.Maximum cortex focal consistently increase by approximately 30% average when present CSF volume. Their effect maximum can be emulated reducing conductivity 1.65 S/m 0.85 S/m. In stark contrast that, only weakly affected slightly (∼6%) decrease included.Our results quantify influence fields. Both very consistent. The also a good agreement prior relevant study. solver generator (compatible SimNIBS) available online.