Carboxymethyl chitin and chitosan derivatives: Synthesis, characterization and antibacterial activity

• DOI: 10.1016/j.carpta.2023.100283
• Publication Date: 2023-01-10T07:49:20Z
• Authors: Md. Monarul Islam; Rashedul Islam; S M Mahmudul Hassan; Md.Rezaul Karim; Mohammad Mahbubur...; Shofiur Rahman; Md. Nur Hossain; Dipa Islam; Md. Aftab Ali Shaikh; Paris E. Georghiou
• Keywords: Enterococcus faecalis

Water-soluble carboxymethyl chitin (CMCT) 1a–b, and chitosan (CMCS) 2a–b derivatives were synthesized evaluated for antibacterial activity. The compounds characterized by Fourier transform infrared spectroscopy (FT-IR) X-ray diffraction (XRD). Thermal properties of the studied thermogravimetric analysis (TGA) their surface morphologies examined scanning electron microscopy (SEM). Antibacterial activity (CS) 2 tested against both gram-negative (Shigella flexneri, Enterococcus faecalis, Pseudomonas aeruginosa, Klebsiella pneumoniae, Vibrio paraheamolyticus) gram-positive (Staphylococcus aureus, Bacillus subtilis, cereus) bacterial strains. CS shows antimicrobial all pathogenic bacteria, whereas CMCS 2a Shigella cereus, subtilis. 2b pneumoniae Staphylococcus aureus. CMCT 1a only subtilis 1b paraheamolyticus cereus.