True hyponatremia in the setting of pegasparagase-induced hypertriglyceridemia: A case report

• DOI: 10.1016/j.cca.2022.02.017
• Publication Date: 2022-03-10T15:46:05Z
• Authors: Lily Olayinka; Izmarie Poventud-...; Shajia Rahman Ansari; Emily Garnett; Sridevi Devaraj
• Keywords: Hypertriglyceridemia; 03 medical and health sciences; 0302 clinical medicine; Asparaginase; Humans; Antineoplastic Agents; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Child; Hyponatremia; Polyethylene Glycols; 3. Good health

Pegasparagase (PEG-Asparaginase) induced hypertriglyceridemia is rare in the treatment of lymphoblastic lymphoma in children. We present a case of PEG-asparaginase induced hypertriglyceridemia that was incidentally identified and suspicion of its interference with sodium measurement in the clinical laboratory. The use of a direct ion selective method clarified the presence of true hyponatremia. The patient was treated with an oral Fenofibrate therapy which resolved the hypertriglyceridemia. This case highlights that PEG-asparaginanse and Olazanpine can induce hypertriglyceridemia in acute lymphoblastic leukemia and it may be useful to obtain baseline triglyceride measurements for these patients.