Synthetic HLA-independent T cell receptors for cancer immunotherapy

• DOI: 10.1016/j.ccell.2022.03.009
• Publication Date: 2022-04-11T14:31:08Z
• Authors: Sylvain Simon; Grace Bugos; Stanley R. Riddell
• Keywords: Cancer Immunotherapy

CAR T cells are remarkably effective in hematologic malignancies, but tumor cells expressing low antigen levels can escape elimination. In Nature Medicine, Mansilla-Soto et al. design new chimeric receptors that link the variable regions of antibodies directly to T cell receptor chains and recognize tumor cells with improved antigen sensitivity.