SWI/SNF regulation of germinal center fate and lymphomagenesis

• DOI: 10.1016/j.ccell.2024.02.006
• Publication Date: 2024-03-07T17:52:30Z
• Authors: Quinlan Sievers; Omar Abdel-Wahab
• Keywords: ARID1A; SMARCA4

The mSWI/SNF subunits ARID1A and SMARCA4 are mutated in B cell lymphomas. Now, Barisic et al. and Deng et al. find that loss of ARID1A or SMARCA4 contributes to lymphomagenesis by causing B cells to aberrantly re-enter germinal centers where they undergo repeated rounds of proliferation and somatic hypermutation.