Recent catalytic syntheses of trifluoromethylthio-containing organic compounds by transition metals, chiral organocatalysts, and photocatalysts

• DOI: 10.1016/j.cclet.2017.02.006
• Publication Date: 2017-02-15T11:00:27Z
• Authors: Yong Guo; Mei-Wei Huang; Xiao-Lin Fu; Chao Liu; Qing-Yun Chen; Zhi-Gang Zhao; Ben-Zhong Zeng; Jiong Chen
• Keywords: Organic Synthesis

Abstract This review summarizes the recent advances in the catalytic syntheses of CF 3 S-containing organic molecules using various nucleophilic or electrophilic trifluoromethylthiolating reagents. C–halogen and C H bonds in various molecules have been transformed to C SCF 3 bonds by transition-metal-catalyzed reactions, such as cross-coupling of aryl halides. Enantioselective reactions controlled by chiral metal complexes or chiral organocatalysts have afforded many trifluoromethylthiolated chiral architectures, such as β -ketoesters and oxindoles. Very recently, visible-light-induced photoredox trifluoromethylthiolations have been developed, providing versatile CF 3 S-containing structures efficiently.