Decoquinate derivatives: A new class of potent antischistosomal agents against Schistosoma japonicum

• DOI: 10.1016/j.cclet.2017.03.036
• Publication Date: 2017-03-31T00:02:46Z
• Authors: Wen-Long Wang; Li-Jun Song; Bo-Chun Hu; Li Miao; Xiao-Yu Chen; Wen-Hua Fan; Xu-Ren Yin; Shuang Shen; Zhao-Feng Ding; Chuan-Xin Yu
• Keywords: 0301 basic medicine; 0303 health sciences; 03 medical and health sciences; 3. Good health

Abstract Decoquinate ( 1 ), an old and inexpensive coccidiostat, exhibited potent antimalarial activity, however, its antischistosomal activity against Schistosoma japonicum has not yet been evaluated. Based on decoquinate, a series of decoquinate derivatives was designed, synthesized, evaluated as a new class of antischistosomal agents against S. japonicum adult worms in vitro . Among them, compound 15 killed 100% of adult S. japonicum in 72 h at the concentration of 10 μmol/L in vitro , exhibited stronger worm-killing activity than PZQ in vitro and could serve as a promising lead compound to develop new antischistosomal agents.