The local microenvironment drives activation of neutrophils in human brain tumors

• DOI: 10.1016/j.cell.2023.08.043
• Publication Date: 2023-09-27T18:38:32Z
• Authors: Roeltje R. Maas; Klara Soukup; Nadine Fournier; Matteo Massara; Sabine Galland; Mara Kornete; Vladimir Wischnewski; Joao Lourenco; Davide Croci; Ángel F. Álvarez-...; Damien N. Marie; Johanna Lilja; Rachel Marcone; Gabriel F. Calvo; Rui Santalla Mendez; Pauline Aubel; Leire Bejarano; Pratyaksha Wirapati; Iván Ballesteros; Andrés Hidalgo; Andreas F. Hottinger; Jean-Philippe Bro...; Roy T. Daniel; Monika E. Hegi; Johanna A. Joyce
• Keywords: Brain tumor; Glial tumor

Neutrophils are abundant immune cells in the circulation and frequently infiltrate tumors substantial numbers. However, their precise functions different cancer types remain incompletely understood, including brain microenvironment. We therefore investigated neutrophils tumor tissue of glioma metastasis patients, with matched peripheral blood, herein describe first in-depth analysis neutrophil phenotypes these tissues. Orthogonal profiling strategies humans mice revealed that tumor-associated (TANs) differ significantly from blood have a prolonged lifespan immune-suppressive pro-angiogenic capacity. TANs exhibit distinct inflammatory signature, driven by combination soluble mediators necrosis factor alpha (TNF-ɑ) Ceruloplasmin, which is more pronounced versus glioma. Myeloid cells, macrophages, emerge at core this network pro-inflammatory mediators, supporting concept critical myeloid niche regulating overall suppression human tumors.