On the Expansion of “Dangerous” Gene Repertoires by Whole-Genome Duplications in Early Vertebrates

• DOI: 10.1016/j.celrep.2012.09.034
• Publication Date: 2012-11-15T17:45:25Z
• Authors: Param Priya Singh; Séverine Affeldt; Ilaria Cascone; Rasim Selimoglu; Jacques Camonis; Hervé Isambert
• Keywords: Negative selection

The emergence and evolutionary expansion of gene families implicated in cancers other severe genetic diseases is an oddity from a natural selection perspective. Here, we show that prone to deleterious mutations the human genome have been preferentially expanded by retention "ohnolog" genes two rounds whole-genome duplication (WGD) dating back onset jawed vertebrates. We further demonstrate many ohnologs suspected be dosage balanced fact indirectly mediated their susceptibility mutations. This enhanced "dangerous" ohnologs, defined as autosomal-dominant mutations, shown consequence WGD-induced speciation ensuing purifying post-WGD species. These findings highlight importance nonadaptive for vertebrate complexity, while rationalizing, perspective, frequently disorders cancers.