dSir2 in the Adult Fat Body, but Not in Muscles, Regulates Life Span in a Diet-Dependent Manner

• DOI: 10.1016/j.celrep.2012.11.013
• Publication Date: 2012-12-13T15:24:31Z
• Authors: Kushal Kr. Banerjee; Champakali Ayyub; Syed Zeeshan Ali; Vinesh Mandot; Nagaraj G. Prasad; Ullas Kolthur-See...
• Keywords: Life span; Model Organism

Sir2, an evolutionarily conserved NAD+-dependent deacetylase, has been implicated as a key factor in mediating organismal life span. However, recent contradictory findings have brought into question the role of Sir2 and its orthologs regulating longevity. In this study, we report that Drosophila (dSir2) adult fat body regulates longevity diet-dependent manner. We used inducible Gal4 drivers to knock down overexpress dSir2 tissue-specific A span phenotype perturbations (both knockdown overexpression) body, but not muscles, negates effects background genetic mutations. addition providing clarity field, our study contrasts ability two metabolic tissues affect also show abrogates fat-body dFOXO-dependent extension. This highlights importance interplay between factors dietary inputs determining spans.