Specificity of Monosynaptic Sensory-Motor Connections Imposed by Repellent Sema3E-PlexinD1 Signaling

• DOI: 10.1016/j.celrep.2013.10.005
• Publication Date: 2013-11-07T12:01:33Z
• Authors: Kaori Fukuhara; Fumiyasu Imai; David R. Ladle; Kei-ichi Katayama; Jennifer R. Leslie; Silvia Arber; Thomas M. Jessell; Yutaka Yoshida
• Keywords: Proprioception

In mammalian spinal cord, group Ia proprioceptive afferents form selective monosynaptic connections with a select of motor pool targets. The extent to which sensory recognition neurons contributes the selectivity sensory-motor remains unclear. We show here that express PlexinD1 avoid forming in Sema3E+ pools yet are able direct Sema3Eoff pools. Anatomical and electrophysiological analysis mice Sema3E-PlexinD1 signaling has been deregulated or inactivated genetically reveals repellent underlies aspects specificity connectivity these reflex arcs. A semaphorin-based system neuron repulsion therefore formation specific cord.