Input- and Cell-Type-Specific Endocannabinoid-Dependent LTD in the Striatum

• DOI: 10.1016/j.celrep.2014.12.005
• Publication Date: 2014-12-24T17:20:01Z
• Authors: Yu-Wei Wu; Jae-Ick Kim; Vivianne L. Tawfik; Rupa R. Lalchandani; Grégory Scherrer; Jun B. Ding
• Keywords: Motor Neurons; 0303 health sciences; 571; Neuronal Plasticity; QH301-705.5; Long-Term Synaptic Depression; Gene Expression; Basal Ganglia; Corpus Striatum; Mice; 03 medical and health sciences; Receptor, Cannabinoid, CB1; Thalamus; Synapses; Animals; Learning; Biology (General); Endocannabinoids

Changes in basal ganglia plasticity at the corticostriatal and thalamostriatal levels are required for motor learning. Endocannabinoid-dependent long-term depression (eCB-LTD) is known to be a dominant form of synaptic expressed these glutamatergic inputs; however, whether eCB-LTD can induced all inputs on striatal neurons still debatable. Using region-specific Cre mouse lines combined with optogenetic techniques, we directly investigated distinguished between projections. We found that was successfully synapses, independent postsynaptic spiny projection neuron (SPN) subtype. Conversely, only nominally present synapses. This dichotomy attributable minimal expression cannabinoid type 1 (CB1) receptors terminals. Furthermore, coactivation dopamine SPNs during LTD induction re-established SPN-subtype-dependent eCB-LTD. Altogether, our findings lay groundwork understanding