Coordination between Translation and Degradation Regulates Inducibility of mGluR-LTD

• DOI: 10.1016/j.celrep.2015.02.020
• Publication Date: 2015-03-05T17:30:36Z
• Authors: Matthew E. Klein; Pablo E. Castillo; Bryen A. Jordan
• Keywords: Long-term depression

Dendritic protein homeostasis is crucial for most forms of long-term synaptic plasticity, and its dysregulation linked to a wide range brain disorders. Current models metabotropic glutamate receptor mediated depression (mGluR-LTD) suggest that rapid, local synthesis key proteins necessary the induction expression LTD. Here, we find mGluR-LTD can be induced in absence translation if proteasome concurrently inhibited. We report enhanced proteasomal degradation during depletes dendritic inhibits subsequent inductions Moreover, inhibition rescue mice null RNA binding Sam68, which show here lack mGluR-dependent Our study provides mechanistic insights how changes abundance regulate induction. propose Sam68-mediated helps counterbalance degradation, ensuring levels briefly remain above permissive threshold LTD