Cilia Disassembly with Two Distinct Phases of Regulation
Organelle
Motile cilium
Basal body
DOI:
10.1016/j.celrep.2015.02.044
Publication Date:
2015-03-24T18:50:52Z
AUTHORS (4)
ABSTRACT
Cilia and flagella are dynamic organelles that undergo assembly disassembly during each cell cycle. They structurally polarized, the mechanisms by which these disassembled incompletely understood. Here, we show flagellar resorption occurs in two distinct phases of length-dependent regulation. A CDK-like kinase, encoded shortening 1 (FLS1), is required for normal rate only distal part flagellum. Mechanistically, loss function FLS1 prevents initial phosphorylation CALK, an aurora-like kinase regulates shortening, induces earlier onset inhibitory CrKinesin13, a microtubule depolymerase, involved shortening. In addition, CALK CrKinesin13 can also be induced process itself, demonstrating example cilia-generated signaling not requiring binding ligand or stimulation ion channel.
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