ATM and ATR Signaling Regulate the Recruitment of Human Telomerase to Telomeres

• DOI: 10.1016/j.celrep.2015.10.041
• Publication Date: 2015-11-12T19:26:41Z
• Authors: Adrian S. Tong; J. Lewis Stern; Agnel Sfeir; Melissa Kartawinata; Titia de Lange; Xu-Dong Zhu; Tracy M. Bryan
• Keywords: Telomerase RNA component; Shelterin; Telomere-binding protein

The yeast homologs of the ATM and ATR DNA damage response kinases play key roles in telomerase-mediated telomere maintenance, but role ATM/ATR mammalian telomerase pathway has been less clear. Here, we demonstrate requirement for localization to telomeres elongation immortal human cells. Stalled replication forks increased recruitment an ATR-dependent manner. Furthermore, was observed upon phosphorylation shelterin component TRF1 at target site (S367). This leads loss from may therefore increase fork stalling. depletion reduced assembly complex, required cells expressing POT1ΔOB, allele POT1 that disrupts telomere-length homeostasis. These data establish are modulated by DNA-damage-transducing kinases.