Evidence for an Age-Dependent Decline in Axon Regeneration in the Adult Mammalian Central Nervous System

• DOI: 10.1016/j.celrep.2016.03.028
• Publication Date: 2016-04-02T02:34:00Z
• Authors: Cédric G. Geoffroy; Brett J. Hilton; Wolfram Tetzlaff; Binhai Zheng
• Keywords: Axotomy

How aging impacts axon regeneration after CNS injury is not known. We assessed the impact of age on induced by Pten deletion in corticospinal and rubrospinal neurons, two neuronal populations with distinct innate regenerative abilities. As young mice, older mice remains effective preventing axotomy-induced decline neuron-intrinsic growth state, as mTOR activity, soma size, axonal proximal to a spinal cord injury. However, distal greatly diminished, accompanied increased expression astroglial inflammatory markers at site. Thus, mammalian undergoes an age-dependent regeneration, revealed when state elevated. These results have important implications for developing strategies promote repair injuries or diseases, which increasingly affect middle-aged populations.