Sustained E2F-Dependent Transcription Is a Key Mechanism to Prevent Replication-Stress-Induced DNA Damage

• DOI: 10.1016/j.celrep.2016.04.036
• Publication Date: 2016-05-05T18:09:48Z
• Authors: Cosetta Bertoli; Anna E. Herlihy; Betheney R. Penny...; Janos Kriston-Vizi; Robertus A.M. de ...
• Keywords: E2F; Transcription

Recent work established DNA replication stress as a crucial driver of genomic instability and key event at the onset cancer. Post-translational modifications play an important role in cellular response to by regulating activity components prevent replication-stress-induced damage. Here, we establish far greater for transcriptional control determining outcome events than previously suspected. Sustained E2F-dependent transcription is both required sufficient many checkpoint functions, including fork stalling, stabilization, resolution. Importantly, also find that, context oncogene-induced stress, where increased E2F thought cause limit levels These data suggest model which cells experiencing through deregulation become addicted cope with high stress.