Loss of Myelin Basic Protein Function Triggers Myelin Breakdown in Models of Demyelinating Diseases

• DOI: 10.1016/j.celrep.2016.06.008
• Publication Date: 2016-06-25T11:41:31Z
• Authors: Marie-Theres Weil; Wiebke Möbius; Anne Winkler; Torben Ruhwedel; Claudia Wrzos; Elisa Romanelli; Jeffrey L. Bennett; Lukas Enz; Norbert Goebels; Klaus-Armin Nave; Martin Kerschenst...; Nicole Schaeren-W...; Christine Stadelmann; Mikael Simons
• Keywords: Proteolipid protein 1; Demyelinating disease

Breakdown of myelin sheaths is a pathological hallmark several autoimmune diseases the nervous system. We employed autoantibody-mediated animal models demyelinating diseases, including rat model neuromyelitis optica (NMO), to target and found that lamellae are broken down into vesicular structures at innermost region sheath. demonstrated basic proteins (MBP), which form polymer in between membrane layers, targeted these models. Elevation intracellular Ca2+ levels resulted MBP network disassembly vesiculation. propose aberrant phase transition molecules from their cohesive soluble non-adhesive state mechanism triggering breakdown NMO possibly other diseases.