PML at Mitochondria-Associated Membranes Is Critical for the Repression of Autophagy and Cancer Development

• DOI: 10.1016/j.celrep.2016.07.082
• Publication Date: 2016-08-22T20:51:42Z
• Authors: Sonia Missiroli; Massimo Bonora; Simone Patergnani; Federica Poletti; Mariasole Perrone; Roberta Gafà; Eros Magri; Andrea Raimondi; Giovanni Lanza; Carlo Tacchetti; Guido Kroemer; Pier Paolo Pandolfi; Paolo Pinton; Carlotta Giorgi
• Keywords: Promyelocytic leukemia protein; Autophagosome

The precise molecular mechanisms that coordinate apoptosis and autophagy in cancer remain to be determined. Here, we provide evidence the tumor suppressor promyelocytic leukemia protein (PML) controls autophagosome formation at mitochondria-associated membranes (MAMs) and, thus, induction. Our vitro vivo results demonstrate how PML functions as a repressor of autophagy. loss promotes development, providing growth advantage cells use cell survival strategy during stress conditions. These findings inhibition could paired with chemotherapeutic agent develop anticancer strategies for tumors present downregulation.