Mesenchymal Stem Cell-Induced DDR2 Mediates Stromal-Breast Cancer Interactions and Metastasis Growth

• DOI: 10.1016/j.celrep.2016.12.079
• Publication Date: 2017-01-31T12:31:47Z
• Authors: Maria E. Gonzalez; Emily E. Martin; Talha Anwar; Caroline Arellano...; Natasha Medhora; Arjun Lama; Yu-Chih Chen; Kevin S. Tanager; Euisik Yoon; Kelley M. Kidwell; Chunxi Ge; Renny T. Franceschi; Celina G. Kleer
• Keywords: Discoidin domain

Increased collagen deposition by breast cancer (BC)-associated mesenchymal stem/multipotent stromal cells (MSC) promotes metastasis, but the mechanisms are unknown. Here, we report that receptor discoidin domain 2 (DDR2) is essential for stromal-BC communication. In human BC DDR2 concordantly upregulated in metastatic and multipotent cells. MSCs isolated from maintains a fibroblastic phenotype with induces pathological activation of signaling Loss impairs their ability to promote phosphorylation cells, as well cell alignment, migration, metastasis. Female ddr2-deficient mice homozygous slie mutation show inefficient spontaneous These results point role stem metastasis suggest therapeutic approach BC.