Neuropilin-1 Is Expressed on Lymphoid Tissue Residing LTi-like Group 3 Innate Lymphoid Cells and Associated with Ectopic Lymphoid Aggregates

• DOI: 10.1016/j.celrep.2017.01.063
• Publication Date: 2017-02-14T21:17:47Z
• Authors: Medya Mara Shikha...; Åsa K. Björklund; Jenny Mjösberg; Jonas S. Erjefält; Anne S. Cornelissen; Xavier Romero Ros; Suzanne M. Bal; Jasper J. Koning; Reina E. Mebius; Michiko Mori; Melanie Bruchard; Bianca Blom; Hergen Spits
• Keywords: Innate lymphoid cell; Ectopic expression

Highlights•NRP1+ ILC3s are present in lymphoid tissues, but not the peripheral blood or skin•NRP1+ express CD45RO and produce higher amounts of cytokines than NRP1− ILC3s•NRP1 is a marker for human with LTi phenotype vitro activity•NRP1+ lung tissues from smokers COPD patientsSummaryHere, we characterize subset that Neuropilin1 (NRP1) skin. NRP1+ group 3 innate cells (ILC3s) display tissue inducer (LTi) activity. In agreement this, mainly located proximity to high endothelial venules (HEVs) cell surface molecules involved lymphocyte migration secondary via HEVs. NRP1 was also expressed on mouse fetal cells, indicating conserved cells. Human primed because they which CD45RA. The ligand vascular growth factor A (VEGF-A) served as chemotactic ILC3s. patients chronic obstructive pulmonary disease, suggesting role angiogenesis and/or initiation ectopic aggregates.Graphical abstract