Canonical Wnt Signaling Ameliorates Aging of Intestinal Stem Cells

• DOI: 10.1016/j.celrep.2017.02.056
• Publication Date: 2017-03-14T16:16:42Z
• Authors: Kodandaramireddy ...; Kalpana J. Nattamai; Rupali S. Kumar; Rebekah Karns; Kathryn A. Wikenh...; Leesa L. Sampson; Maxime M. Mahe; Nambirajan Sundaram; Mary-Beth Yacyshyn; Bruce Yacyshyn; Michael A. Helmrath; Yi Zheng; Hartmut Geiger
• Keywords: Organoid; Mesenchyme

Although intestinal homeostasis is maintained by stem cells (ISCs), regeneration impaired upon aging. Here, we first uncover changes in architecture, cell number, and composition Second, identify a decline the regenerative capacity of ISCs aging because canonical Wnt signaling ISCs. Changes expression Wnts are found themselves their niche, including Paneth mesenchyme. Third, reactivating enhances function both murine human and, thus, ameliorates aging-associated phenotypes an organoid assay. Our data demonstrate role for physiological further potential therapeutic avenues to improve ISC