Action Selection and Flexible Switching Controlled by the Intralaminar Thalamic Neurons

Action selection Stimulus (psychology)
DOI: 10.1016/j.celrep.2018.02.016 Publication Date: 2018-02-27T16:39:49Z
ABSTRACT
Learning processes contributing to appropriate selection and flexible switching of behaviors are mediated through the dorsal striatum, a key structure basal ganglia circuit. The major inputs striatal subdivisions provided from intralaminar thalamic nuclei, including central lateral nucleus (CL) parafascicular (PF). Thalamostriatal neurons in PF modulate acquisition performance stimulus-response learning. Here, we address roles CL thalamostriatal learning by using selective neural pathway targeting technique. We show that essential for behavioral flexibility, reversal attentional set-shifting learned responses. In addition, chemogenetic suppression activity supports requirements these flexibility. Our results suggest main contribution is functional control circuit linked prefrontal cortex.
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