Autophagy Ablation in Adipocytes Induces Insulin Resistance and Reveals Roles for Lipid Peroxide and Nrf2 Signaling in Adipose-Liver Crosstalk

• DOI: 10.1016/j.celrep.2018.10.040
• Publication Date: 2018-11-13T15:43:32Z
• Authors: Jinjin Cai; Karla M. Pires; Maroua Ferhat; Bhagirath Chaurasia; Márcio A. Buffolo; Rana Smalling; Ashot Sargsyan; Donald L. Atkinson; Scott A. Summers; Timothy E. Graham; Sihem Boudina
• Keywords: Crosstalk; Lipid droplet; Lipid peroxide

Autophagy is a homeostatic cellular process involved in the degradation of long-lived or damaged components. The role autophagy adipogenesis well recognized, but its mature adipocyte function largely unknown. We show that proteins Atg3 and Atg16L1 are required for proper mitochondrial adipocytes. In contrast to previous studies, we found post-developmental ablation causes peripheral insulin resistance independently diet adiposity. Finally, lack reveals cross talk between fat liver, mediated by lipid peroxide-induced Nrf2 signaling. Our data reveal preventing peroxide formation transfer insulin-sensitive tissues.