HDAC3 Regulates the Transition to the Homeostatic Myelinating Schwann Cell State

• DOI: 10.1016/j.celrep.2018.11.045
• Publication Date: 2018-12-04T16:02:35Z
• Authors: Laura H. Rosenberg; Anne-Laure Cattin; Xavier Fontana; Elizabeth Harford...; Jemima J. Burden; Ian J. White; Jacob G. Smith; Ilaria Napoli; Victor Quereda; Cristina Policarpi; Jamie Freeman; Robin Ketteler; Antonella Riccio; Alison C. Lloyd
• Keywords: HDAC3; HDAC1; Histone deacetylase 2; Homeostasis; Schwann cell

The formation of myelinating Schwann cells (mSCs) involves the remarkable biogenic process, which rapidly generates myelin sheath. Once formed, mSC transitions to a stable homeostatic state, with loss this stability associated neuropathies. histone deacetylases deacetylase 1 (HDAC1) and HDAC2 are required for myelination transcriptional program. Here, we show distinct role HDAC3, in that, while dispensable mSCs, it is essential sheath once formed—with resulting progressive severe neuropathy adulthood. This prior failure downregulate program upon entering state leading hypertrophy hypermyelination progressing development defects. Our results highlight roles HDAC1/2 HDAC3 controlling differentiation states cell broad implications understanding important cell-state transition.