Fasting Imparts a Switch to Alternative Daily Pathways in Liver and Muscle

• DOI: 10.1016/j.celrep.2018.11.077
• Publication Date: 2018-12-18T15:39:44Z
• Authors: Kenichiro Kinouchi; Christophe Magnan; Nicholas Ceglia; Yu Liu; Marlene Cervantes; Nunzia Pastore; Tuong Huynh; Andrea Ballabio; Pierre Baldi; Selma Masri; Paolo Sassone-Corsi
• Keywords: Zeitgeber

The circadian clock operates as intrinsic time-keeping machinery to preserve homeostasis in response the changing environment. While food is a known zeitgeber for clocks peripheral tissues, it remains unclear how lack of influences function. We demonstrate that transcriptional fasting through molecular mechanisms are distinct from time-restricted feeding regimens. First, affects core genes and proteins, resulting blunted rhythmicity BMAL1 REV-ERBα both liver skeletal muscle. Second, induces switch temporal gene expression dedicated fasting-sensitive transcription factors such GR, CREB, FOXO, TFEB, PPARs. Third, rhythmic genomic sustainable by prolonged reversible refeeding. Thus, imposes specialized dynamics coordination between nutrient-sensitive pathways, thereby achieving fasting-specific regulation.