Immunotherapeutic Blockade of CD47 Inhibitory Signaling Enhances Innate and Adaptive Immune Responses to Viral Infection

• DOI: 10.1016/j.celrep.2020.03.058
• Publication Date: 2020-04-14T14:58:24Z
• Authors: Lamin B. Cham; Laughing Bear Tor...; Michal Caspi Tal; Tom Adomati; Fanghui Li; Hilal Bhat; Anfei Huang; Philipp A. Lang; Mary E. Moreno; Jose M. Rivera; Sofiya A. Galkina; Galina Kosikova; Cheryl A. Stoddart; Joseph M. McCune; Lara M. Myers; Irving L. Weissman; Karl S. Lang; Kim J. Hasenkrug
• Keywords: CD47

Paradoxically, early host responses to infection include the upregulation of antiphagocytic molecule, CD47. This suggests that CD47 blockade could enhance antigen presentation and subsequent immune responses. Indeed, mice treated with anti-CD47 monoclonal antibody following lymphocytic choriomeningitis virus infections show increased activation both macrophages dendritic cells (DCs), enhancement kinetics potency CD8+ T cell responses, significantly improved control. Treatment efficacy is critically dependent on APCs cells. In preliminary results from one two cohorts humanized infected HIV-1 for 6 weeks, reduces plasma p24 levels restores CD4+ counts. The indicate not only enhances function innate but also links adaptive through APC function. As such, immunotherapy by may have broad applicability treat a wide range infectious diseases.